Removal of sodium inactivation and block of sodium channels by chloramine-T in crayfish and squid giant axons
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چکیده
منابع مشابه
Removal of sodium channel inactivation in squid axon by the oxidant chloramine-T
We have investigated the effects of a mild oxidant, chloramine-T(CT), on the sodium and potassium currents of squid axons under voltage-clamp conditions. Sodium channel inactivation of squid giant axons can be completely removed by CT at neutral pH. Internal and external CT treatment are both effective. CT apparently removes inactivation in an irreversible, all-or-none manner. The activation pr...
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The group-specific protein reagents, N-bromacetamide (NBA) and N-bromosuccinimide (NBS), modify sodium channel gating when perfused inside squid axons. The normal fast inactivation of sodium channels is irreversibly destroyed by 1 mM NBA or NBS near neutral pH. NBA apparently exhibits an all-or-none destruction of the inactivation process at the single channel level in a manner similar to inter...
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The group-specific protein reagents, N-bromoacetamide (NBA) and N-bromosuccinimide (NBS), modify sodium channel gating when perfused inside squid axons. The normal fast inactivation of sodium channels is irreversibly destroyed by 1 mM NBA or NBS near neutral pH. NBA apparently exhibits an allor-none destruction of the inactivation process at the single channel level in a manner similar to inter...
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TASAKI, ICHIJI, IRWIN SINGER, AND AKIRA WATANABE. Excitation of squid giant axons in sodium-free external media. Am. J. Physiol, 2 I I (3) : 746-754. rg66.-Studies of membrane impedance and potential variation were made on squid giant axons under sodium-free external conditions. Intracellular perfusion by the double-cannulation method was employed. It was found that with favorable internal cond...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1987
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(87)83203-4